Trimix Peptide Therapy: Everything You Need To Know

Trimix: Benefits, Uses, Dosage and More

Erectile dysfunction is a problem that most men don’t think about until it begins to impact them. Many men take the ease of attaining an erection for granted, and when that ability is diminished, it can leave a man feeling defeated and decrease their confidence.

Whether you are experiencing symptoms of ED or have full dexterity of your erectile function, learning more about this common issue can help alleviate some of the barriers to seeking care.

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Elite HRT

Written by Elite HRT
on June 09, 2021

Medically reviewed by

Camille Frecking, Regulatory Affairs Specialist, MEDICAL ADVISOR


Many men only know a couple of things about ED and one of those is that penile injection therapy is one of the potential treatments. While most men fair well with prescription PDE5 inhibitors like Viagra or Cialis, penile injections may be required to restore full functioning. Needles and self-injection therapy can be intimidating at first, however, penile injections can be an effective means of attaining and sustaining an erection for those that have not found success with oral medicine.

Below is a closer look at Trimix. Understanding everything there is to know about Trimix will better prepare you for what to expect at your first doctor’s visit and what you should look out for while using it. 

Being informed about your treatments allows you the best chance of getting positive outcomes and catching unforeseen issues early. 

What is Trimix?

Trimix is a penile injection that is utilized as a treatment for erectile dysfunction. The name Trimix is derived from the fact that three different active ingredients are mixed together in one solution, hence “tri-mix.” The three ingredients include prostaglandin E1, phentolamine, and papaverine. Each ingredient acts in a specific manner to assist the erectile tissues of the penis to attain an erection. Below is a closer look at each active ingredient and what role it plays in assisting with an erection. 

Prostaglandin E1

Prostaglandin E1 is a hormone-like molecule that can directly alter the dilation properties within the penis. The structure known as the corpus cavernosum is a hollowed structure that fills with blood, which causes an erection. Prostaglandin E1 can increase the inflow of blood while also decreasing the outflow of blood. This is accomplished by prostaglandins’ ability to cause smooth muscle relaxation and dilation of vessels in the corpus cavernosum. The result is blood accumulation in the corpus cavernosum and an erection. 


Phentolamine is considered an alpha-adrenoceptor antagonist. That may be a mouthful, but phentolamine essentially blocks the binding of epinephrine and norepinephrine. Both epinephrine and norepinephrine can cause vasoconstriction in the penis which results in a lack of blood and ED. With a dose of phentolamine, these erection inhibitors are unable to bind to their receptors, which can allow the blood vessels to dilate. With dilated blood vessels, blood can enter the corpus cavernosum and an erection can be achieved. 


Papaverine is considered an alkaloid and it can cause the smooth muscles of the surrounding blood vessels to relax and allow blood flow. In this way, papaverine is a potent vasodilator and works by inhibiting the breakdown of key molecules responsible for vasodilation. These molecules are cAMP and cGMP. With higher concentrations of cAMP and cGMP the blood vessels surrounding the area dilate and allow more blood flow. 

How To Use Trimix

Trimix is only one of a few self-administered injections that can be utilized to treat erectile dysfunction. Understanding how to safely use Trimix is an important aspect of getting the most out of your treatment and ensuring you hit the least amount of speed bumps during your treatment. 

Below is a brief overview of how to use Trimix. The overview serves to give you an idea of what to expect and you should seek professional instruction from your healthcare provider to ensure you are following the proper techniques. 

When prescribed Trimix, your provider will most likely walk through your first injection during the visit to ensure you utilize proper technique and to ensure the dosage is appropriate for the desired effects. If you are unsure about administration, consult with your doctor for clarification and further training. 


With self-administered injections, the key is proper preparation. While an injection site is tiny, since it is puncturing the surface of the skin, it poses the risk of infection. The largest emphasis during preparation is to ensure the tools and surfaces you are dealing with are sterile.

The first steps include a thorough hand washing and sanitization of the rubber stopper using an alcohol pad. Next, take a sterile syringe, remove the cap, and pull it back to the approximate dose you want in order to fill the syringe with air. Insert the needle into the top of the vial and push the air into the vial. Then, put the needle into the fluid portion and pull up the correct amount of medication — it will usually display in mg/mL. Take the needle out and invert it so the needle is pointing toward the ceiling. If any air is present it should float to the top. Depress the plunger to remove any excess air bubbles, and keep depressing until the medication is visible at the tip of the needle — this is also known as priming the needle. 


With the syringe ready to go, generously wipe the injection site at the side of the shaft with a new alcohol pad and wait for it to air dry. Ensure you avoid large blood vessels when choosing an injection site. 

To make for easier penetration of the needle and less pain, take your index finger and thumb and do a reverse pinching motion to stretch the skin of the injection site, making it more taut. 

Take the needle and insert it straight into the penis, and slowly depress the plunger. Remove the needle, cover the site with a finger and safely discard the needle. 

With your finger covering the injection site, gently massage the penis to ensure even distribution of the medication. Try to keep your finger over the injection site for several minutes to ensure no leakage of the medication. 

Trimix Dosage

Trimix like many medications can be administered in many different volumes and can come in many different concentrations. Trimix dosage can be broken down into two different ways. The first is the relative amount of each ingredient and the other is the amount that you utilize per injection. Understanding these differences can allow you to ensure you are getting the best dose to achieve and retain an erection. 


Based on the results of the initial injection, your physician may choose to increase or decrease your dosage volume, also known as the amount that you pull up through the syringe. 


When you first see a vial of Trimix, it can be easy to get lost with the label. Typically you will see two distinct sections where one provides the ingredients, while the other section has numbers. 

The ingredients will be listed in a format that resembles the following:

Papaverine / Phentolamine / Prostaglandin

The numbers will be laid out in a similar fashion where they are separated by slashes. An example would look something like this:

150 mg / 5 mg / 50 mcg / vial

In the above example, there is 150 mg of papaverine, 5 mg phentolamine, and 50 mcg of prostaglandin per vial. Knowing how much of each ingredient is in the vial can help you to understand what your current dosage is. 

Other Erectile Dysfunction Medication

While Trimix has a relatively high success rate, it isn’t for everyone. Some forms of ED don’t have as much to do with physical dysfunction, but a decreased desire to have sex in the first place. 

Low libido is a common cause of diminishing sexual intimacy and a large contributor to a loss in libido could be a decrease in hormones within the body. To assist with low libido associated with low hormone levels, hormone replacement therapy can be an invaluable treatment option. 

Elite HRT is a leader in hormone replacement therapy and is ready to help in whatever way we can. Whether you are looking to restore testosterone or HGH levels, or utilize the power of nutraceuticals, Elite HRT is ready to help with specialized physicians and tailored programs. Every individual and situation is unique, and we can provide you with a tailor-made treatment plan to help get you back to where you want to be. 


In summary, Trimix is a drug mixture that contains prostaglandin E1, phentolamine, and papaverine. While each ingredient independently can help aid an erection, when the three are combined it produces a highly effective means of getting an erection. 

Understanding how each ingredient plays its role as well as the proper administration and dosage is important to ensure the treatment is effective. 

While your healthcare provider will go through this information with you during your appointment, being prepared ahead of time can allow you to better retain and understand the information.


TRIMIX injections, ED injections, Trimix for ED

Prostaglandin E1 – StatPearls – NCBI Bookshelf

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